We consider cancer cytotoxic drugs as an optimal control problem essie blush worthy to stabilize a heterogeneous tumor by attacking not the most abundant cancer cells, but those that are crucial in the tumor ecosystem.We propose a mathematical cancer stem cell model that translates the hierarchy and heterogeneity of cancer cell types by including h
Background: Hypoxia and consequent production of casual azul tequila vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases.Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed.Methods: Oxygen-induced retinopathy was used as a model to test the role of nitric oxide
As a cryptography primitive for secure data transmission, certificateless proxy signcryption (CLPS) allows an original signcrypter to entrust his signing authority to a proxy signcrypter for signing specified message on his behalf.In this paper, we combine CLPS with cyclic multiplication groups (CMGs) to construct a new certificateless proxy signcr
Jacqueline A Pesa1, Jill Van Den Bos2, Travis Gray2, Colleen Hartsig2, Robert Brett McQueen3, Joseph J Saseen3, Kavita V Nair31Janssen Scientific Affairs, LLC, Louisville, CO, USA; 2Milliman, Inc, Denver, CO, USA; 3University of Colorado Anschutz Medical Campus, Aurora, CO, USAObjective: To assess the impact of patient cost-sharing for antihyperten
Abstract.A new method of enzyme-linked moen finney immunosorbent assay (in solid-phase ELISA format) has been developed to determine concentrations of autoantibodies to glutamic acid decarboxylase, as well as an evidencebased methodology is proposed for its medical implications, as a quantitative pathogenetic predictive marker of autoimmune pete cr